N-bromobutanimide → HCID 70463777, compound

Participants

Reaction Steps

A clear solution was obtained after refluxing a suspension of 371.8 mg (1.07 mmoles) of 3-methyl-7-phenylacetamido-3-cephem-4-carboxylic acid-1-oxide and 284.7 mg (1.65 mmoles) of N-trimethylsilyldiacetamide in 40 ml of dichloromethane for 5 minutes and it was cooled in an ice-bath and brominated in half an hour with 290.2 mg (1.63 mmoles) of N-bromosuccinimide to obtain a 47% yield of trimethylsilyl 3-bromomethyl-7-phenylacetamido-3-cephem-4-carboxylate-1-oxide.

Provenance & Evidence