反应详情

324 mg (1.63 mmoles) of N-methyl-N-trimethylsilyltrifluoroacetamide were added to a suspension of 409 mg (1.22 mmoles) of 7-benzamido-3-methyl-3-cephem-4-carboxylic acid-1-oxide in 25 ml of dichloromethane and after stirring at room temperature for 10 minutes, a clear, slightly yellow solution was obtained. This was diluted to 40 ml with dicloromethane and 50 mg of amidosulfonic acid (0.51 mmole) were added. This solution was cooled in an ice-bath and was brominated in one hour with 301 mg (1.70 mmoles) of N-bromosuccinimide to obtain a yield of 59% of trimethylsilyl 7-benzamido-3-bromomethyl-3-cephem-4-carboxylate-1-oxide.

1. customa clear, slightly yellow solution was obtained
2. additionwere added
3. temperatureThis solution was cooled in an ice-bath