Hydrochloric Acid → HCID 20467708, compound

Participants

Reaction Steps

To a solution of 19.7 g. (0.056 moles) of diethyl N-(2-ethoxycarbonylethyl)-N-(chloroacetyl)-amino-malonate prepared according to Example 2 in 200 ml. of dry benzene 13 ml. (9.5 g., 0.095 moles) of triethyl amine are added and the reaction mixture is boiled for 3 hours. The solution is shaken with two 50-ml. portions of a 5% aqueous hydrochloric acid solution and subsequently with 50 ml. of water, the benzene phase is dried with magnesium sulfate, filtered and the filtrate is evaporated in vacuo. 16.5 g. (93%) of the named compound are obtained. The product is practically uniform and can be used for further conversions without further purification.

Provenance & Evidence