Hydrochloric Acid → HCID 20467708, compound

HRID 1903006Notes

Reaction equation

HRID 1903006 reaction equation
[CH2:1]([O:3][C:4]([CH2:6][CH2:7][N:8]([CH:13]([C:19]([O:21][CH2:22][CH3:23])=[O:20])[C:14]([O:16][CH2:17][CH3:18])=[O:15])[C:9](=[O:12])[CH2:10]Cl)=[O:5])[CH3:2].C(N(CC)CC)C.Cl>C1C=CC=CC=1>[CH2:1]([O:3][C:4]([CH2:6][CH2:7][N:8]1[C:9](=[O:12])[CH2:10][C:13]1([C:19]([O:21][CH2:22][CH3:23])=[O:20])[C:14]([O:16][CH2:17][CH3:18])=[O:15])=[O:5])[CH3:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 8471TriethylamineHCID 54028900HCID 54028900, compound

Product 1

HCID 20467708HCID 20467708, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

To a solution of 19.7 g. (0.056 moles) of diethyl N-(2-ethoxycarbonylethyl)-N-(chloroacetyl)-amino-malonate prepared according to Example 2 in 200 ml. of dry benzene 13 ml. (9.5 g., 0.095 moles) of triethyl amine are added and the reaction mixture is boiled for 3 hours. The solution is shaken with two 50-ml. portions of a 5% aqueous hydrochloric acid solution and subsequently with 50 ml. of water, the benzene phase is dried with magnesium sulfate, filtered and the filtrate is evaporated in vacuo. 16.5 g. (93%) of the named compound are obtained. The product is practically uniform and can be used for further conversions without further purification.

Workup

  1. dry with materialof water, the benzene phase is dried with magnesium sulfate
  2. filtrationfiltered
  3. customthe filtrate is evaporated in vacuo

Sources & evidence

ORD record
ord-7bc9b477e6e1442a8fb66d4db613bfa4
Source dataset
uspto-grants-1984_03
Patent number
US04435322

Reaction notes

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