Hydrochloric Acid → HCID 14456866, compound

Participants

Reaction Steps

47.6 g. (0.162 moles) of ethyl-1-(2,4-dimethoxybenzyl)-4-oxo-2-azetidine-carboxylate prepared according to Example 10 are reacted with 12.4 g. (0.327 moles) of sodium tetrahydrido-borate(III), in 200 ml. of methanol, under outer cooling with ice water for about half an hour. The solution is neutralized with a dilute aqueous hydrochloric acid solution and the oil precipitated from the aqueous mixture is shaken with five 50-ml. portions of ethyl acetate.

Provenance & Evidence