Hydrochloric Acid → HCID 14456866, compound

HRID 1903011Notes

Reaction equation

HRID 1903011 reaction equation
C([O:3][C:4]([CH:6]1[CH2:9][C:8](=[O:10])[N:7]1[CH2:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][C:13]=1[O:20][CH3:21])=O)C.Cl>CO>[CH3:21][O:20][C:13]1[CH:14]=[C:15]([O:18][CH3:19])[CH:16]=[CH:17][C:12]=1[CH2:11][N:7]1[CH:6]([CH2:4][OH:3])[CH2:9][C:8]1=[O:10]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 13505933HCID 13505933, compound

Product 1

HCID 14456866HCID 14456866, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

47.6 g. (0.162 moles) of ethyl-1-(2,4-dimethoxybenzyl)-4-oxo-2-azetidine-carboxylate prepared according to Example 10 are reacted with 12.4 g. (0.327 moles) of sodium tetrahydrido-borate(III), in 200 ml. of methanol, under outer cooling with ice water for about half an hour. The solution is neutralized with a dilute aqueous hydrochloric acid solution and the oil precipitated from the aqueous mixture is shaken with five 50-ml. portions of ethyl acetate.

Workup

  1. customare reacted with 12.4 g
  2. customthe oil precipitated from the aqueous mixture

Sources & evidence

ORD record
ord-510e8c1cfcc44b52a5f039fbd1aad0dd
Source dataset
uspto-grants-1984_03
Patent number
US04435322

Reaction notes

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