Hydrochloric Acid → HCID 568802, compound

Participants

Reaction Steps

To a dilution of 106.5 g. (0.486 moles) of ethyl 1-phenyl-4-oxo-2-azetidine-carboxylate prepared according to Example 24 in 700 ml. of methanol 18.74 g. (0.493 moles) of sodium tetrahydrido-borate(III) are added with outer cooling with ice water and stirring. The mixture is acidified with dilute hydrochloric acid and it is then neutralized with disodium hydrogenphosphate. Methanol is distilled off in vacuo. 65 g. (76%) of the named compound are obtained, melting at 100° to 102° C. (ethyl acetate/petroleum ether).

Provenance & Evidence