Hydrochloric Acid → HCID 568802, compound

HRID 1903015Notes

Reaction equation

HRID 1903015 reaction equation
[C:1]1([N:7]2[C:10](=[O:11])[CH2:9][CH:8]2[C:12](OCC)=[O:13])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.P([O-])([O-])(O)=O.[Na+].[Na+]>CO>[C:1]1([N:7]2[CH:8]([CH2:12][OH:13])[CH2:9][C:10]2=[O:11])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 24203Sodium Phosphate, DibasicHCID 12479106HCID 12479106, compound

Product 1

HCID 568802HCID 568802, compoundYield 76%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a dilution of 106.5 g. (0.486 moles) of ethyl 1-phenyl-4-oxo-2-azetidine-carboxylate prepared according to Example 24 in 700 ml. of methanol 18.74 g. (0.493 moles) of sodium tetrahydrido-borate(III) are added with outer cooling with ice water and stirring. The mixture is acidified with dilute hydrochloric acid and it is then neutralized with disodium hydrogenphosphate. Methanol is distilled off in vacuo. 65 g. (76%) of the named compound are obtained, melting at 100° to 102° C. (ethyl acetate/petroleum ether).

Workup

  1. distillationMethanol is distilled off in vacuo

Sources & evidence

ORD record
ord-7156552f74684ac7bda19e085ce9e4ce
Source dataset
uspto-grants-1984_03
Patent number
US04435322

Reaction notes

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