HCID 13135604, compound → HCID 70478116, compound

HRID 1903062Notes

Reaction equation

HRID 1903062 reaction equation
[CH2:1]([O:3][CH2:4][C:5]([O:7][C@:8]1([C@:29]2([CH3:30])[C@H:15]([C@H:16]3[C@H:26]([C@@H:27]([OH:31])[CH2:28]2)[C@:24]2([CH3:25])[C:19](=[CH:20][C:21](=[O:32])[CH:22]=[CH:23]2)[C@@H:18]([CH3:33])[CH2:17]3)[CH2:14][CH2:13]1)[C:9](=[O:12])[CH2:10][OH:11])=[O:6])[CH3:2]>C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.[Cl-].[Rh]>[CH2:1]([O:3][CH2:4][C:5]([O:7][C@:8]1([C@:29]2([CH3:30])[C@H:15]([C@H:16]3[C@H:26]([C@@H:27]([OH:31])[CH2:28]2)[C@:24]2([CH3:25])[C:19](=[CH:20][C:21](=[O:32])[CH2:22][CH2:23]2)[C@@H:18]([CH3:33])[CH2:17]3)[CH2:14][CH2:13]1)[C:9](=[O:12])[CH2:10][OH:11])=[O:6])[CH3:2]

Participants

3

Reactant 1

HCID 13135604HCID 13135604, compound

Product 1

HCID 70478116HCID 70478116, compoundYield 78.7%

Reagents, catalysts & solvents 1

HCID 84599Chlorotris(triphenylphosphine)rhodium(I)Catalyst

Procedure

1.0 g of 17-ethoxyacetoxy-11β,21-dihydroxy-6α-methyl-1,4-pregnadiene-3,20-dione is hydrogenated as described in Example 19 with 700 mg of tris(triphenylphosphine)rhodium(I) chloride. After the reaction mixture has been worked up and purified, 790 mg of 17-ethoxyacetoxy-11β,21-dihydroxy-6α-methyl-4-pregnene-3,20-dione is isolated.

Workup

  1. custompurified

Sources & evidence

ORD record
ord-655b7c333f09466da6596f3a4933101a
Source dataset
uspto-grants-1984_03
Patent number
US04435390

Reaction notes

Loading…