Methoxyacetyl chloride → 11beta,17-Dihydroxy-21-methoxyacetoxy-6alpha-methyl-4-pregnene-3,20-dione

HRID 1903063ノート

反応式

HRID 1903063 の反応式
[OH:1][C@H:2]1[CH2:22][C@@:21]2([CH3:23])[C@@H:13]([CH2:14][CH2:15][C@:16]2([OH:24])[C:17](=[O:20])[CH2:18][OH:19])[C@H:12]2[C@H:3]1[C@:4]1([CH3:27])[C:9]([C@@H:10]([CH3:25])[CH2:11]2)=[CH:8][C:7](=[O:26])[CH2:6][CH2:5]1.[CH3:28][O:29][CH2:30][C:31](Cl)=[O:32]>>[OH:1][C@H:2]1[CH2:22][C@@:21]2([CH3:23])[C@@H:13]([CH2:14][CH2:15][C@:16]2([OH:24])[C:17](=[O:20])[CH2:18][O:19][C:31](=[O:32])[CH2:30][O:29][CH3:28])[C@H:12]2[C@H:3]1[C@:4]1([CH3:27])[C:9]([C@@H:10]([CH3:25])[CH2:11]2)=[CH:8][C:7](=[O:26])[CH2:6][CH2:5]1

参加物

3

反応物 2

HCID 96623Methoxyacetyl chlorideHCID 1021476alpha-Methylhydrocortisone

生成物 1

HCID 7050179511beta,17-Dihydroxy-21-methoxyacetoxy-6alpha-methyl-4-pregnene-3,20-dione

実験手順

1.5 g of 11β,17,21-trihydroxy-6α-methyl-4-pregnene-3,20-dione is reacted analogously to Example 1(a) with methoxyacetic acid chloride, worked up, and chromatographed, thus isolating 1.6 g of 11β,17-dihydroxy-21-methoxyacetoxy-6α-methyl-4-pregnene-3,20-dione.

後処理

  1. customchromatographed

出典と根拠

ORDレコード
ord-e65678ce00d24710ad0a1e0b2007dc3d
出典データセット
uspto-grants-1984_03
特許番号
US04435390

反応ノート

読み込み中…