反应详情

To 1.0 g of 5,6-dichloro-3-nitropyrazinamine in 15 ml acetyl chloride under nitrogen atmosphere at room temperature is added 0.84 g anhydrous sodium bicarabonate. The reaction mixture is then stirred and heated at reflux for 4 days. Excess acetyl chloride is then removed in vacuo and the residue is chromatographed on silica gel. The desired product is eluted from the column with chloroform.

1. temperatureheated
2. temperatureat reflux for 4 days
3. customExcess acetyl chloride is then removed in vacuo
4. customthe residue is chromatographed on silica gel
5. washThe desired product is eluted from the column with chloroform