反应详情

To 5.0 g (0.051 m) methyl 2-butynoate in 25 ml absolute ethanol was added 5.0 g (0.055 m) 2,3-dihydroxypropylamine. This solution was heated at 75°-80° for 18 hours and the solvent was then removed at reduced pressure. The residue oil was chromatographed on silica gel, eluting with 10% methanol/chloroform to afford the desired product as a white solid, m.p. 109°-111°. The yield was 5.6 g (59%). ##STR5##

1. temperatureThis solution was heated at 75°-80° for 18 hours
2. customthe solvent was then removed at reduced pressure
3. customThe residue oil was chromatographed on silica gel
4. washeluting with 10% methanol/chloroform