HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 9H-pyrido[3,4-b]indole-3-carboxaldehyde oxime
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | Hydroxylamine, N-chloro- | HCID 149953 | — |
| Reactant | 9H-pyrido[3,4-b]indole-3-carbaldehyde | HCID 12789144 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 9H-pyrido[3,4-b]indole-3-carboxaldehyde oxime | HCID 136399276 | 67.3% |
Reaction Steps
A solution of 3.1 g of potassium hydroxide in 40 ml of methanol is added to a mixture of 150 ml of dimethylformamide, 6.9 g of beta-carboline-3-carboxaldehyde and 3.1 g of hydroxylamino-hydrochloride. The reaction mixture is allowed to stand at room temperature overnight. After evaporation, 50 ml of water is added. The reaction product is filtered off. 6.9 g of the air-dried product is heated in the steam bath together with 35 ml of 2 propanol and, after cooling, is filtered off. 5 g of beta-carboline-3-carboxaldehyde-oxime with a melting point of 229°-231° C. is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04435403 |
| Source dataset | uspto-grants-1984_03 |
| ORD ID | ord-787c8a79aa9946eba7d84f3065d1c0d7 |
| Source note | uspto-grants-1984_03 |