Sodium Hydroxide → HCID 178523922, compound

HRID 1903107Notes

Reaction equation

HRID 1903107 reaction equation
Cl.N[OH:3].[OH-].[Na+].C[N:7]([CH:9]=[N:10][C:11]([C:13]1[N:14]=[CH:15][C:16]2[NH:17][C:18]3[C:23]([C:24]=2[CH:25]=1)=[CH:22][CH:21]=[CH:20][CH:19]=3)=[O:12])C>O.C(O)(=O)C>[OH:3][NH:7][CH:9]=[N:10][C:11]([C:13]1[N:14]=[CH:15][C:16]2[NH:17][C:18]3[C:23]([C:24]=2[CH:25]=1)=[CH:22][CH:21]=[CH:20][CH:19]=3)=[O:12]

Participants

6

Reactant 3

HCID 14798Sodium HydroxideHCID 443297Hydroxyamine hydrochlorideHCID 23316511HCID 23316511, compound

Product 1

HCID 178523922HCID 178523922, compoundYield 95.2%

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 962WaterSolvent2×

Procedure

A mixture of 0.35 g of hydroxylamine hydrochloride, 1.5 ml of water, 1.0 ml of 5 N sodium hydroxide, 3.5 ml of acetic acid and 1.1 g of N-[(dimethylamino)methylene]-beta-carboline-3-carboxamide is allowed to stand for 1/2 h at room temperature. After adding 3 ml of water, the white precipitate is filtered off and washed with water. 1.0 g of N-[(hydroxyamino)methylene]-beta-carboline-3-carboxamide with a m.p. of 235°-240° C. is obtained.

Workup

  1. filtrationthe white precipitate is filtered off
  2. washwashed with water

Sources & evidence

ORD record
ord-689de416ee4e49e2be63a7ea759cc086
Source dataset
uspto-grants-1984_03
Patent number
US04435403

Reaction notes

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