反应详情

Add pivaloyl chloride (2.4 ml) in CH2Cl2 (10 ml) to a cooled (0°-5° C.) and stirred solution of N-allyloxycarbonylglycine (3.18 g) and triethylamine (2.8 ml) in dry CH2Cl2 (50 ml). Stir the mixture at 0°-5° C. for 15 mins. and then add a solution of 2-aminoethanethiol hydrochloride (2.4 g) and triethylamine (2.8 ml) in ethanol (15 ml) and CH2Cl2 (40 ml). Stir at room temperature for 1 hour, wash the mixture with aqueous 2 N-H2SO4 and aqueous NaHCO3, dry and evaporate. Triturate the resulting solid with ether, filter and dry to give the title compound.

1. temperaturea cooled (0°-5° C.)
2. stirringStir at room temperature for 1 hour
3. washwash the mixture with aqueous 2 N-H2SO4 and aqueous NaHCO3
4. customdry
5. customevaporate
6. customTriturate the resulting solid with ether
7. filtrationfilter
8. customdry