1,2-Dichloroethane → Ethanol, 2-(cyclohexylamino)-

HRID 1903184Notes

Reaction equation

HRID 1903184 reaction equation
[CH:1]1([NH2:7])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[OH-:8].[Na+].[CH2:10](Cl)[CH2:11]Cl>>[OH:8][CH2:10][CH2:11][NH:7][CH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 3

HCID 111,2-DichloroethaneHCID 7965CyclohexylamineHCID 14798Sodium Hydroxide

Product 1

HCID 17827Ethanol, 2-(cyclohexylamino)-

Conditions

Temperature
160 °C

Procedure

Into 100 g of cyclohexylamine was added 41 g of ethylene chloride and the mixture was stirred at about 160° C. for 10 hours. After cooling the reaction mixture to a room temperature, 100 ml of 10 N-NaOH aqueous solution was added to the reaction mixture and the organic layer was obtained by using a separating funnel and thus obtained organic layer was dried with KOH. KOH was removed by filtration and the mother liquor was distilled under a reduced pressure. 48 Grams of N-(2-hydroxyethyl)cyclohexylamine was obtained as an oily substance. Boiling point: 132°-135° C. (18 mmHg).

Workup

  1. temperatureAfter cooling the reaction mixture to a room temperature
  2. customthe organic layer was obtained
  3. dry with materialthus obtained organic layer was dried with KOH
  4. customKOH was removed by filtration
  5. distillationthe mother liquor was distilled under a reduced pressure

Sources & evidence

ORD record
ord-3fe0b6c7f5a14e6ab91937a2840f7b2d
Source dataset
uspto-grants-1984_03
Patent number
US04435404

Reaction notes

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