HCID 54031169, compound → HCID 13107971, compound

HRID 1903203Notes

Reaction equation

HRID 1903203 reaction equation
[C:1]1([N:7]2[CH2:12][CH2:11][N:10]([C:13]([CH:15]=[CH:16][CH2:17][O:18][C:19]3[CH:20]=[C:21]4[C:26](=[CH:27][CH:28]=3)[NH:25][C:24](=[O:29])[CH:23]=[CH:22]4)=[O:14])[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>CO.[C].[Pd]>[C:1]1([N:7]2[CH2:8][CH2:9][N:10]([C:13]([CH2:15][CH2:16][CH2:17][O:18][C:19]3[CH:20]=[C:21]4[C:26](=[CH:27][CH:28]=3)[NH:25][C:24](=[O:29])[CH:23]=[CH:22]4)=[O:14])[CH2:11][CH2:12]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 1

HCID 54031169HCID 54031169, compound

Product 1

HCID 13107971HCID 13107971, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

1.0 Gram of 6-[3-(4-phenyl-1-piperazinylcarbonyl)-2-propenyloxy]carbostyril was dissolved in 50 ml of methanol, then 0.1 g of 5% palladium-carbon was added thereto. The mixture was catalytically hydrogenated at a room temperature under an atmospheric pressure for 5 hours. After the reaction was completed, the catalyst was removed by filtration and the filtrate was concentrated by distillation under a reduced pressure to dryness. The residue thus obtained was recrystallized from chloroform-petroleum ether to obtain 0.75 g of 6-[3-(4-phenyl-1-piperazinylcarbonyl)propoxy]carbostyril as in the form of colorless needle-like crystals. Melting point 202.5°-203.5° C.

Workup

  1. customthe catalyst was removed by filtration
  2. concentrationthe filtrate was concentrated by distillation under a reduced pressure to dryness
  3. customThe residue thus obtained
  4. customwas recrystallized from chloroform-petroleum ether

Sources & evidence

ORD record
ord-d534e973c5984b6da2e0a63d4d40d622
Source dataset
uspto-grants-1984_03
Patent number
US04435404

Reaction notes

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