HCID 54031169, compound → HCID 13107971, compound

Participants

Reaction Steps

1.0 Gram of 6-[3-(4-phenyl-1-piperazinylcarbonyl)-2-propenyloxy]carbostyril was dissolved in 50 ml of methanol, then 0.1 g of 5% palladium-carbon was added thereto. The mixture was catalytically hydrogenated at a room temperature under an atmospheric pressure for 5 hours. After the reaction was completed, the catalyst was removed by filtration and the filtrate was concentrated by distillation under a reduced pressure to dryness. The residue thus obtained was recrystallized from chloroform-petroleum ether to obtain 0.75 g of 6-[3-(4-phenyl-1-piperazinylcarbonyl)propoxy]carbostyril as in the form of colorless needle-like crystals. Melting point 202.5°-203.5° C.

Provenance & Evidence