Ethanol → Ethyl 6,7-dichloro-2,3-dihydro-1-benzofuran-2-carboxylate
Reaction equation
[Cl:1][C:2]1[CH:13]=[CH:12][C:5]2[CH2:6][CH:7]([C:9]([OH:11])=[O:10])[O:8][C:4]=2[C:3]=1[Cl:14].OS(O)(=O)=O.[CH2:20](O)[CH3:21]>>[Cl:1][C:2]1[CH:13]=[CH:12][C:5]2[CH2:6][CH:7]([C:9]([O:11][CH2:20][CH3:21])=[O:10])[O:8][C:4]=2[C:3]=1[Cl:14]Participants
4
Procedure
A solution of 50 g. of crude 6,7-dichloro-2,3-dihydrobenzofuran-2-carboxylic acid in 500 ml. absolute ethanol was treated with 3 ml. concentrated H2SO4 at reflux for 5 hours under a Soxhlet extractor containing 3A molecular sieves. The solution was then evaporated to dryness, redissolved in ethyl acetate, and washed with agueous saturated NaCl, aqueous saturated NaHCO3, and again aqueous saturated NaCl.
Workup
- customThe solution was then evaporated to dryness
- dissolutionredissolved in ethyl acetate
- washwashed with agueous saturated NaCl, aqueous saturated NaHCO3, and again aqueous saturated NaCl
Sources & evidence
- ORD record
- ord-76a2a6047ec749e7bdff3c4b5dd49585
- Source dataset
- uspto-grants-1984_03
- Patent number
- US04435422
Reaction notes
Loading…