HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → Ethyl 6,7-dichloro-2,3-dihydro-1-benzofuran-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | 6,7-dichloro-2,3-dihydrobenzofuran-2-carboxylic Acid | HCID 9816065 | — |
| Product | Ethyl 6,7-dichloro-2,3-dihydro-1-benzofuran-2-carboxylate | HCID 12747889 | — |
Reaction Steps
A solution of 50 g. of crude 6,7-dichloro-2,3-dihydrobenzofuran-2-carboxylic acid in 500 ml. absolute ethanol was treated with 3 ml. concentrated H2SO4 at reflux for 5 hours under a Soxhlet extractor containing 3A molecular sieves. The solution was then evaporated to dryness, redissolved in ethyl acetate, and washed with agueous saturated NaCl, aqueous saturated NaHCO3, and again aqueous saturated NaCl.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04435422 |
| Source dataset | uspto-grants-1984_03 |
| ORD ID | ord-76a2a6047ec749e7bdff3c4b5dd49585 |
| Source note | uspto-grants-1984_03 |