Hydrochloric Acid → HCID 13300617, compound

HRID 1903211Notes

Reaction equation

HRID 1903211 reaction equation
[Cl:1]CC([NH:5][CH2:6][C:7]1[CH:8]=[C:9]([CH:24]=[CH:25][C:26]=1[OH:27])[CH2:10][C:11]1[C:12]([Cl:23])=[C:13]([Cl:22])[C:14]2[O:18][CH:17]([CH2:19][OH:20])[CH2:16][C:15]=2[CH:21]=1)=O.Cl>C(O)C>[ClH:1].[NH2:5][CH2:6][C:7]1[CH:8]=[C:9]([CH:24]=[CH:25][C:26]=1[OH:27])[CH2:10][C:11]1[C:12]([Cl:23])=[C:13]([Cl:22])[C:14]2[O:18][CH:17]([CH2:19][OH:20])[CH2:16][C:15]=2[CH:21]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 13300614HCID 13300614, compound

Product 1

HCID 13300617HCID 13300617, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The glass from Example 18 (500 mg.) was dissolved in ethanol (20 ml.) and treated with 3 N aqueous HCl (100 ml.) at reflux for four hours. The resulting solution was partially evaporated and chilled on an ice bath to yield a white crystalline precipitate (400 mg., 87.78%), m.p. 227°-230° (dec.).

Workup

  1. temperatureat reflux for four hours
  2. customThe resulting solution was partially evaporated
  3. temperaturechilled on an ice bath
  4. customto yield a white crystalline precipitate (400 mg., 87.78%), m.p. 227°-230° (dec.)

Sources & evidence

ORD record
ord-2a99b33d7cc14a629df5d43aa5658710
Source dataset
uspto-grants-1984_03
Patent number
US04435422

Reaction notes

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