Water → HCID 13194908, compound

HRID 1903213Notes

Reaction equation

HRID 1903213 reaction equation
[OH:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[C:10](=[O:12])[CH2:9][CH2:8][CH2:7]2.[CH2:13]([CH:15]1[O:17][CH2:16]1)Cl.[OH-].[Na+].O>COCCO>[O:1]=[C:2]1[C:11]2[C:10]([O:12][CH2:13][CH:15]3[O:17][CH2:16]3)=[CH:9][CH:8]=[CH:7][C:6]=2[CH2:5][CH2:4][CH2:3]1

Participants

6

Reactant 4

HCID 962WaterHCID 7835EpichlorohydrinHCID 14798Sodium HydroxideHCID 5843538-Hydroxy-3,4-dihydronaphthalen-1(2H)-one

Product 1

HCID 13194908HCID 13194908, compound

Reagents, catalysts & solvents 1

HCID 80192-MethoxyethanolSolvent

Procedure

To the solution heated to 80° C. of 3.2 g of 8-hydroxy 1-tetralone and 20 ml of epichlorohydrin in 20 ml of 2-methoxy ethanol is added 1.8 g of sodium hydroxide and the mixture is heated to reflux for 1 hour. Water is added and the mixture is extracted with methylene chloride. The organic phase is separated, dried and the solvent is evaporated.

Workup

  1. temperaturethe mixture is heated
  2. temperatureto reflux for 1 hour
  3. extractionthe mixture is extracted with methylene chloride
  4. customThe organic phase is separated
  5. customdried
  6. customthe solvent is evaporated

Sources & evidence

ORD record
ord-1f1dc561fc2d4992940ae3bc4f72fa44
Source dataset
uspto-grants-1984_03
Patent number
US04435426

Reaction notes

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