HCID 13273321, compound → HCID 13273322, compound

HRID 1903242Notes

Reaction equation

HRID 1903242 reaction equation
[F:1][CH:2]([F:22])[C:3]([C:15]([O:17]C(C)(C)C)=[O:16])([CH2:11][CH2:12][CH:13]=[CH2:14])[C:4]([O:6]C(C)(C)C)=[O:5]>FC(F)(F)C(O)=O>[C:15]([C:3]([CH:2]([F:1])[F:22])([CH2:11][CH2:12][CH:13]=[CH2:14])[C:4]([OH:6])=[O:5])([OH:17])=[O:16]

Participants

3

Reactant 1

HCID 13273321HCID 13273321, compound

Product 1

HCID 13273322HCID 13273322, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

2-Difluoromethyl 2(tert-butoxycarbonyl)-5-hexenoic acid, tert-butyl ester prepared as in Step B (5 mM, 1.600 g) is dissolved in trifluoroacetic acid (10 ml) at 0° C. After stirring for 1.5 hours at room temperature, the solvent is evaporated in vacuo yielding a white solid. 1.040 g (quantitative yield). Mp: 80°-81° C.

Workup

  1. customthe solvent is evaporated in vacuo
  2. customyielding a white solid

Sources & evidence

ORD record
ord-1e2125984a1e4bfcbf3b8f8c24dd8237
Source dataset
uspto-grants-1984_03
Patent number
US04435425

Reaction notes

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