HCID 13273322, compound → 2-(Difluoromethyl)hex-5-enoic acid

HRID 1903243Notes

Reaction equation

HRID 1903243 reaction equation
[C:1]([C:4]([CH:12]([F:14])[F:13])([CH2:8][CH2:9][CH:10]=[CH2:11])C(O)=O)([OH:3])=[O:2]>C(O)(=O)C>[F:13][CH:12]([F:14])[CH:4]([CH2:8][CH2:9][CH:10]=[CH2:11])[C:1]([OH:3])=[O:2]

Participants

3

Reactant 1

HCID 13273322HCID 13273322, compound

Product 1

HCID 132733232-(Difluoromethyl)hex-5-enoic acidYield 71%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
110 °C

Procedure

2-Carboxy 2-difluoromethyl 5-hexenoic acid, prepared as in Step C (1.040 g, 5 mM) is dissolved in glacial acetic acid (5 ml) and the mixture is heated at 110° C. for 16 hours. The solvent is evaporated in vacuo yielding a colorless oil. The acid is isolated by distillation under reduced pressure. 0.585 g (yield 71%). Bp: 67° C./0.01 mm Hg.

Workup

  1. customThe solvent is evaporated in vacuo
  2. customyielding a colorless oil
  3. customThe acid is isolated by distillation under reduced pressure

Sources & evidence

ORD record
ord-a910656b234743efa0dc2c514ab18484
Source dataset
uspto-grants-1984_03
Patent number
US04435425

Reaction notes

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