HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diiodomethane → Bicifadine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diiodomethane | HCID 6346 | — |
| Reactant | HCID 3024855 | HCID 3024855 | — |
| Catalyst | Copper | HCID 23978 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | Bicifadine | HCID 47953 | — |
Reaction Steps
A mixture of 3-(p-tolyl)-3-pyrroline, methylene iodide, and powdered copper in a molar ration of 1:2:4 is heated in benzene for about 50 hours. Filtration and evaporation of the solution gives 1-(p-tolyl)-3-azabicyclo[3.1.0]hexane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04435419 |
| Source dataset | uspto-grants-1984_03 |
| ORD ID | ord-67f402ae0a6640d2b0a6e50f5d17463b |
| Source note | uspto-grants-1984_03 |