Propionyl chloride → HCID 20468337, compound

HRID 1903274Notes

Reaction equation

HRID 1903274 reaction equation
Cl.[C:2]1([C:8]23[CH2:13][CH:12]2[CH2:11][NH:10][CH2:9]3)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl-].[Al+3].[Cl-].[Cl-].[C:18]([Cl:22])(=[O:21])[CH2:19][CH3:20]>ClCCl>[ClH:22].[C:8]12([C:2]3[CH:3]=[CH:4][C:5]([C:18](=[O:21])[CH2:19][CH3:20])=[CH:6][CH:7]=3)[CH2:13][CH:12]1[CH2:11][NH:10][CH2:9]2

Participants

5

Reactant 3

HCID 62324Propionyl chlorideHCID 6451240Aluminum(III) ChlorideHCID 127198431-Phenyl-3-azabicyclo[3.1.0]hexane hydrochloride

Product 1

HCID 20468337HCID 20468337, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of 5.6 g. of 1-phenyl-3-azabicyclo[3.1.0]hexane hydrochloride, 12.9 g. of aluminum chloride and 6.2 g. of propionyl chloride in 55 ml. of dichloromethane is reacted as described in Example 57, to give 4.5 g. of the desired product, m.p. 191°-193° C.

Workup

  1. additionA mixture of 5.6 g
  2. customto give 4.5 g

Sources & evidence

ORD record
ord-0852d275431840e9915a1297d9177f5d
Source dataset
uspto-grants-1984_03
Patent number
US04435419

Reaction notes

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