Acetone → 1-(4-methoxyphenyl)-3-phenylurea

HRID 1903292Notes

Reaction equation

HRID 1903292 reaction equation
[CH3:1][O:2][C:3]1[CH:9]=[CH:8][CH:7]=[CH:6][C:4]=1N.C([N:12](CC)CC)C.CC(C)=O.[SH2]=N.[C:23]1([NH:29][C:30](C2C=CC=CC=2C(O)=O)=[O:31])[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>O>[C:23]1([NH:29][C:30]([NH:12][C:7]2[CH:8]=[CH:9][C:3]([O:2][CH3:1])=[CH:4][CH:6]=2)=[O:31])[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1

Participants

6

Reactant 4

HCID 180AcetoneHCID 70002-MethoxyanilineHCID 8471TriethylamineHCID 178514671HCID 178514671, compound

Product 1

HCID 3028471-(4-methoxyphenyl)-3-phenylurea

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 0.6 g o-methoxyaniline and 0.7 ml triethylamine with 5 ml aceton was added dropwise to a suspension of 1.5 g phenylcarbamoyl-benzoic acid sulfimide, under stirring. The reaction mixture was stirred at room temperature for 2 hours, then diluted with 100 ml water. The precipitated solid product was cooled, filtered, washed with water and dried. 0.80 g 1-phenyl-3-(4-methoxyphenyl)-urea was obtained, which melted at 196°-198° C.

Workup

  1. stirringThe reaction mixture was stirred at room temperature for 2 hours
  2. temperatureThe precipitated solid product was cooled
  3. filtrationfiltered
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-cd35c993f6894deca97d52f21af93045
Source dataset
uspto-grants-1984_03
Patent number
US04435567

Reaction notes

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