1-Methylpiperazine → HCID 13392734, compound

HRID 1903308Notes

Reaction equation

HRID 1903308 reaction equation
Cl[C:2]1[N:3]=[C:4]([NH:12][CH2:13][CH2:14][OH:15])[C:5]2[S:11][CH2:10][CH2:9][CH2:8][C:6]=2[N:7]=1.[CH3:16][N:17]1[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]1>>[OH:15][CH2:14][CH2:13][NH:12][C:4]1[C:5]2[S:11][CH2:10][CH2:9][CH2:8][C:6]=2[N:7]=[C:2]([N:20]2[CH2:21][CH2:22][N:17]([CH3:16])[CH2:18][CH2:19]2)[N:3]=1

Participants

3

Reactant 2

HCID 531671-MethylpiperazineHCID 13307217HCID 13307217, compound

Product 1

HCID 13392734HCID 13392734, compoundYield 95.3%

Procedure

In the same manner as described in Example 20, 6 g of 2-chloro-4-(2-hydroxyethyl)amino-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidine was reacted with 15 g of N-methylpiperazine to obtain 7.2 g of 4-(2-hydroxyethyl)amino-2-(N-methylpiperazino)-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidine which was then recrystallized from methanol-diethyl ether. Colorless prisms. Melting point: 162°-164° C.

Sources & evidence

ORD record
ord-6422d738c7c042c6a244ff6da72d5a4f
Source dataset
uspto-grants-1984_03
Patent number
US04435566

Reaction notes

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