Piperazine → HCID 13307208, compound

HRID 1903309Notes

Reaction equation

HRID 1903309 reaction equation
Cl[C:2]1[N:3]=[C:4]([NH:12][CH2:13][CH2:14][OH:15])[C:5]2[S:11][CH2:10][CH2:9][CH2:8][C:6]=2[N:7]=1.[NH:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1>>[OH:15][CH2:14][CH2:13][NH:12][C:4]1[C:5]2[S:11][CH2:10][CH2:9][CH2:8][C:6]=2[N:7]=[C:2]([N:16]2[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]2)[N:3]=1

Participants

3

Reactant 2

HCID 4837PiperazineHCID 13307217HCID 13307217, compound

Product 1

HCID 13307208HCID 13307208, compound

Procedure

In the same manner as described in Example 17, 2-chloro-4-(2-hydroxyethyl)amino-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidine was reacted with anhydrous piperazine to obtain 4-(2-hydroxyethyl)amino-2-piperazino-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidine which was then recrystallized from ethanol. Colorless needles. Melting point: 116°-120° C.

Sources & evidence

ORD record
ord-356121e75a5d4f96abd4461167fb996f
Source dataset
uspto-grants-1984_03
Patent number
US04435566

Reaction notes

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