Benzyl Chloride → 2-Amino-5-dibenzylaminomethylpyrrolo[2,3-d]pyrimidin-4-one

https://huagongshe.com/reaction/1903314

Participants

Role	Name	HCID	Charge
Reactant	Benzyl Chloride	HCID 7503	—
Reactant	Potassium Carbonate	HCID 11430	—
Reactant	2-Amino-5-benzylaminomethylpyrrolo[2,3-d]pyrimidin-4-one	HCID 20468540	—
Catalyst	Sodium Iodide	HCID 5238	—
Solvent	Methanol	HCID 887	—
Product	2-Amino-5-dibenzylaminomethylpyrrolo[2,3-d]pyrimidin-4-one	HCID 20246372	24.9%

Reaction Conditions

Temperature	60 °C

Reaction Steps

In 30 ml of methanol was dissolved 172 mg of 2-amino-5-benzylaminomethylpyrrolo[2,3-d]pyrimidin-4-one (the compound of Example 4), followed by addition of 90 mg of anhydrous potassium carbonate, 2 mg of sodium iodide and 81 mg of benzyl chloride. The mixture was stirred on a water bath at 60° C. for 4 hrs. The solvent was then distilled off and the residue was purified by silica gel column chromatography to give 57 mg of the desired compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US04435569
Source dataset	uspto-grants-1984_03
ORD ID	ord-502030615bf548bc96bcac359d882794
Source note	uspto-grants-1984_03