反应详情

温度

60 °C

In 30 ml of methanol was dissolved 172 mg of 2-amino-5-benzylaminomethylpyrrolo[2,3-d]pyrimidin-4-one (the compound of Example 4), followed by addition of 90 mg of anhydrous potassium carbonate, 2 mg of sodium iodide and 81 mg of benzyl chloride. The mixture was stirred on a water bath at 60° C. for 4 hrs. The solvent was then distilled off and the residue was purified by silica gel column chromatography to give 57 mg of the desired compound.

1. distillationThe solvent was then distilled off
2. customthe residue was purified by silica gel column chromatography