HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1903339Generated: October 29, 2026
Trifluoroacetic acid → H-(D)Trp-Lys(Z)-OMe hydrochloride
https://huagongshe.com/reaction/1903339
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Ether hydrochloride | HCID 10953452 | — |
| Reactant | BOC-(D)Trp-Lys(Z)-OMe | HCID 13391303 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | H-(D)Trp-Lys(Z)-OMe hydrochloride | HCID 13391306 | — |
Reaction Steps
150 ml TFA are added to 30 g BOC-(D)Trp-Lys(Z)-OMe in 150 ml methylene chloride pre-cooled to 0° C. The whole is stirred for 40 minutes at room-temperature and then added to 30 ml HCl/ethyl-ether (~5 N) in 4 l ethyl-ether. After thorough stirring the precipitate is filtered off, washed with ethyl-ether and dried to yield the title compound:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04435385 |
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| Source dataset | uspto-grants-1984_03 |
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| ORD ID | ord-758c82f3ccaf4e8484c977c337b64009 |
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| Source note | uspto-grants-1984_03 |
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