HRID1903339

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6422

未命名化合物

HCID10953452

未命名化合物

结构：COC(=O)[C@H](CCCCNC(=O)OCc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C

HCID13391303

未命名化合物

PRODUCTS

生成物

结构：COC(=O)[C@H](CCCCNC(=O)OCc1ccccc1)NC(=O)[C@H](N)Cc1c[nH]c2ccccc12.Cl

HCID13391306

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID3283

Diethyl Ether

C4H10O

溶剂HCID6344

Dichloromethane

CH2Cl2

CONDITIONS

反应条件

温度: 0 °C

PROCEDURE

实验过程

150 ml TFA are added to 30 g BOC-(D)Trp-Lys(Z)-OMe in 150 ml methylene chloride pre-cooled to 0° C. The whole is stirred for 40 minutes at room-temperature and then added to 30 ml HCl/ethyl-ether (~5 N) in 4 l ethyl-ether. After thorough stirring the precipitate is filtered off, washed with ethyl-ether and dried to yield the title compound:

WORKUP

后处理

stirringAfter thorough stirring the precipitate
filtrationis filtered off
washwashed with ethyl-ether
customdried

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-758c82f3ccaf4e8484c977c337b64009
来源数据集: uspto-grants-1984_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04435385
来源说明: uspto-grants-1984_03

反应 SMILES

C(O)(C(F)(F)F)=O.[NH:8](C(OC(C)(C)C)=O)[C@@H:9]([C:20]([NH:22][C@H:23]([C:39]([O:41][CH3:42])=[O:40])[CH2:24][CH2:25][CH2:26][CH2:27][NH:28][C:29]([O:31][CH2:32][C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)=[O:30])=[O:21])[CH2:10][C:11]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[NH:13][CH:12]=1.[ClH:50].C(OCC)C>C(Cl)Cl.C(OCC)C>[NH2:8][C@@H:9]([C:20]([NH:22][C@H:23]([C:39]([O:41][CH3:42])=[O:40])[CH2:24][CH2:25][CH2:26][CH2:27][NH:28][C:29]([O:31][CH2:32][C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)=[O:30])=[O:21])[CH2:10][C:11]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[NH:13][CH:12]=1.[ClH:50]