HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → H-Phe-(D)Trp-Lys(Z)-Thr-Cys(MBzl)-Thr-ol hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | BOC-Phe-(D)Trp-Lys(Z)-Thr-Cys(MBzl)-Thr-ol | HCID 131713420 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Trifluoroacetic acid water | HCID 22392675 | — |
| Product | H-Phe-(D)Trp-Lys(Z)-Thr-Cys(MBzl)-Thr-ol hydrochloride | HCID 131713421 | — |
Reaction Steps
13 g BOC-Phe-(D)Trp-Lys(Z)-Thr-Cys(MBzl)-Thr-ol are dissolved in 60 ml cold TFA/H2O (15:1) and the solution allowed to stand for 30 min. at room temperature. The reaction mixture is stirred into a mixture comprising 3 liters ethyl-ether and 20 ml HCl in ethyl-ether (~5 N) and the precipitated product filtered off, washed with ethyl-ether and dried to yield the title compound:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04435385 |
| Source dataset | uspto-grants-1984_03 |
| ORD ID | ord-37b3c6a1be8748ec9f8dd6ccf5c2e844 |
| Source note | uspto-grants-1984_03 |