HRID1903343

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

结构：Cc1ccc(CSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCNC(=O)OCc2ccccc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)OC(C)(C)C)[C@@H](C)O)C(=O)N[C@H](CO)[C@@H](C)O)cc1

HCID131713420

未命名化合物

PRODUCTS

生成物

结构：Cc1ccc(CSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCNC(=O)OCc2ccccc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)Cc2ccccc2)[C@@H](C)O)C(=O)N[C@H](CO)[C@@H](C)O)cc1.Cl

HCID131713421

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID3283

Diethyl Ether

C4H10O

2 次

溶剂HCID22392675

未命名化合物

PROCEDURE

实验过程

13 g BOC-Phe-(D)Trp-Lys(Z)-Thr-Cys(MBzl)-Thr-ol are dissolved in 60 ml cold TFA/H2O (15:1) and the solution allowed to stand for 30 min. at room temperature. The reaction mixture is stirred into a mixture comprising 3 liters ethyl-ether and 20 ml HCl in ethyl-ether (~5 N) and the precipitated product filtered off, washed with ethyl-ether and dried to yield the title compound:

WORKUP

后处理

filtrationthe precipitated product filtered off
washwashed with ethyl-ether
customdried

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-37b3c6a1be8748ec9f8dd6ccf5c2e844
来源数据集: uspto-grants-1984_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04435385
来源说明: uspto-grants-1984_03

反应 SMILES

[NH:1](C(OC(C)(C)C)=O)[C@H:2]([C:10]([NH:12][C@@H:13]([C:24]([NH:26][C@H:27]([C:43]([NH:45][C@H:46]([C:50]([NH:52][C@H:53]([C:64]([NH:66][C@H:67]([CH2:71][OH:72])[C@@H:68]([CH3:70])[OH:69])=[O:65])[CH2:54][S:55][CH2:56][C:57]1[CH:63]=[CH:62][C:60]([CH3:61])=[CH:59][CH:58]=1)=[O:51])[C@@H:47]([CH3:49])[OH:48])=[O:44])[CH2:28][CH2:29][CH2:30][CH2:31][NH:32][C:33]([O:35][CH2:36][C:37]1[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1)=[O:34])=[O:25])[CH2:14][C:15]1[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[NH:17][CH:16]=1)=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[ClH:80]>C(O)(C(F)(F)F)=O.O.C(OCC)C>[NH2:1][C@H:2]([C:10]([NH:12][C@@H:13]([C:24]([NH:26][C@H:27]([C:43]([NH:45][C@H:46]([C:50]([NH:52][C@H:53]([C:64]([NH:66][C@H:67]([CH2:71][OH:72])[C@@H:68]([CH3:70])[OH:69])=[O:65])[CH2:54][S:55][CH2:56][C:57]1[CH:63]=[CH:62][C:60]([CH3:61])=[CH:59][CH:58]=1)=[O:51])[C@@H:47]([CH3:49])[OH:48])=[O:44])[CH2:28][CH2:29][CH2:30][CH2:31][NH:32][C:33]([O:35][CH2:36][C:37]1[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=1)=[O:34])=[O:25])[CH2:14][C:15]1[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[NH:17][CH:16]=1)=[O:11])[CH2:3][C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1.[ClH:80]