Water → HCID 131713423, compound

HRID 1903344Notes

Reaction equation

HRID 1903344 reaction equation
[NH:1](C(OC(C)(C)C)=O)[C@@H:2]([C:10]([NH:12][C@H:13]([C:24]([OH:26])=[O:25])[CH2:14][S:15][CH2:16][C:17]1[CH:23]=[CH:22][C:20]([CH3:21])=[CH:19][CH:18]=1)=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.O.C(OCC)C.[ClH:40]>C(O)(C(F)(F)F)=O.C(OCC)C>[NH2:1][C@@H:2]([C:10]([NH:12][C@H:13]([C:24]([OH:26])=[O:25])[CH2:14][S:15][CH2:16][C:17]1[CH:23]=[CH:22][C:20]([CH3:21])=[CH:19][CH:18]=1)=[O:11])[CH2:3][C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1.[ClH:40]

Participants

6

Reactant 3

HCID 962WaterHCID 10953452Ether hydrochlorideHCID 131713425HCID 131713425, compound

Product 1

HCID 131713423HCID 131713423, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

5 g BOC-(D)Phe-Cys(MBzl)-OH are dissolved in 80 ml TFA and 10 ml H2O and allowed to stand for 45 minutes at room-temperature. The solution is diluted with ethyl-ether and 20 ml ethyl-ether/HCl (~5 N) are added, and the precipitate is filtered off, washed with ethyl ether and dried to yield the title compound:

Workup

  1. additionare added
  2. filtrationthe precipitate is filtered off
  3. washwashed with ethyl ether
  4. customdried

Sources & evidence

ORD record
ord-9e7eaadea97c44ab98d526fb168c394d
Source dataset
uspto-grants-1984_03
Patent number
US04435385

Reaction notes

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