Ethylamine → HCID 13057017, compound

HRID 1903369Notes

Reaction equation

HRID 1903369 reaction equation
[CH2:1]([NH2:3])[CH3:2].CO[C:6](=[O:28])[C@H:7]([CH2:20][C:21]1[CH:26]=[CH:25][C:24]([F:27])=[CH:23][CH:22]=1)[NH:8][C:9](=[O:19])[CH2:10][NH:11][C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13]>>[C:15]([O:14][C:12]([NH:11][CH2:10][C:9]([NH:8][C@H:7]([C:6]([NH:3][CH2:1][CH3:2])=[O:28])[CH2:20][C:21]1[CH:22]=[CH:23][C:24]([F:27])=[CH:25][CH:26]=1)=[O:19])=[O:13])([CH3:16])([CH3:17])[CH3:18]

Participants

3

Reactant 2

HCID 6341EthylamineHCID 13057015HCID 13057015, compound

Product 1

HCID 13057017HCID 13057017, compound

Procedure

To 12 g of cooled liquid ethylamine in a small pressure bottle is added 2.8 g of t-boc-gly-4-F-phe OCH3, 6b, and the solution stirred overnight at room temperature. Evaporation of the solvent gives a solid, which when recrystallized from 95% ethanol yields 8b, m.p. 181°-182.5° C. Alternatively, 8b may be prepared from 7b, according to the procedure of Example 8a.

Workup

  1. customEvaporation of the solvent
  2. customgives a solid, which when
  3. customrecrystallized from 95% ethanol

Sources & evidence

ORD record
ord-3379e59ae89647ec8d2c04772bde454e
Source dataset
uspto-grants-1984_03
Patent number
US04435571

Reaction notes

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