Tert-Butylamine → HCID 20467336, compound

Participants

Reaction Steps

12.5 g (60 mM) 4-(2,3-epoxypropyloxy)-2,1,3-benzthiadiazole were dissolved in 150 ml. n-butanol and, after the addition of 40 ml. tert.-butylamine, heated under reflux for 3 hours. When the reaction was finished, the reaction mixture was evaporated and the residue was chromatographed on a silica gel column in the manner described in Example 1. There were obtained 9.6 g (57% of theory) 4-(3-tert.-butylamino-2-hydroxy-propyloxy)-2,1,3-benzthiadiazole, which had a melting point of 89°-91° C.

Provenance & Evidence