Tert-Butylamine → HCID 20467336, compound

HRID 1903402Notes

Reaction equation

HRID 1903402 reaction equation
[O:1]1[CH2:14][CH:2]1[CH2:3][O:4][C:5]1[C:13]2[C:9](=[N:10][S:11][N:12]=2)[CH:8]=[CH:7][CH:6]=1.[C:15]([NH2:19])([CH3:18])([CH3:17])[CH3:16]>C(O)CCC>[C:15]([NH:19][CH2:14][CH:2]([OH:1])[CH2:3][O:4][C:5]1[C:13]2[C:9](=[N:10][S:11][N:12]=2)[CH:8]=[CH:7][CH:6]=1)([CH3:18])([CH3:17])[CH3:16]

Participants

4

Reactant 2

HCID 6385Tert-ButylamineHCID 13064030HCID 13064030, compound

Product 1

HCID 20467336HCID 20467336, compoundYield 57%

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

12.5 g (60 mM) 4-(2,3-epoxypropyloxy)-2,1,3-benzthiadiazole were dissolved in 150 ml. n-butanol and, after the addition of 40 ml. tert.-butylamine, heated under reflux for 3 hours. When the reaction was finished, the reaction mixture was evaporated and the residue was chromatographed on a silica gel column in the manner described in Example 1. There were obtained 9.6 g (57% of theory) 4-(3-tert.-butylamino-2-hydroxy-propyloxy)-2,1,3-benzthiadiazole, which had a melting point of 89°-91° C.

Workup

  1. temperatureunder reflux for 3 hours
  2. customthe reaction mixture was evaporated
  3. customthe residue was chromatographed on a silica gel column in the manner

Sources & evidence

ORD record
ord-9dfb7a4d305b4933b268e8a24ed5add0
Source dataset
uspto-grants-1984_03
Patent number
US04436742

Reaction notes

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