Ammonia → HCID 20268172, compound

HRID 1903413Notes

Reaction equation

HRID 1903413 reaction equation
C[O:2][C:3]([CH2:5][CH2:6][CH2:7][CH2:8][N:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([CH3:18])=[C:10]1[N:19]1[CH:23]=[CH:22][N:21]=[CH:20]1)=O.[NH3:24]>C(O)CCC>[C:3]([CH2:5][CH2:6][CH2:7][CH2:8][N:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([CH3:18])=[C:10]1[N:19]1[CH:23]=[CH:22][N:21]=[CH:20]1)(=[O:2])[NH2:24]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 20268177HCID 20268177, compound

Product 1

HCID 20268172HCID 20268172, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

A solution of 4 g of 1-(4-methoxycarbonylbutyl)-3-methyl-2-(1-imidazolyl)indole in 40 ml of n-butanol is saturated with ammonia and heated on a steam bath in a pressure bottle for 3 days. The reaction mixture is evaporated to dryness and the product is crystallized to yield the 1-[4-carbamoylbutyl]-3-methyl-2-(1-imidazolyl)indole.

Workup

  1. temperatureheated on a steam bath in a pressure bottle for 3 days
  2. customThe reaction mixture is evaporated to dryness
  3. customthe product is crystallized

Sources & evidence

ORD record
ord-f6e074535f9645dd9623da6ebaed24d0
Source dataset
uspto-grants-1984_03
Patent number
US04436746

Reaction notes

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