HCID 20467555, compound → Idazoxan

HRID 1903578Notes

Reaction equation

HRID 1903578 reaction equation
C(O)(=O)C.[O:5]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[O:8][CH2:7][CH:6]1[C:15]1[NH:16][CH2:17][CH2:18][N:19]=1>S(=O)(=O)(O)O.C(O)C>[O:5]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[O:8][CH2:7][CH:6]1[C:15]1[NH:16][CH2:17][CH2:18][N:19]=1

Participants

4

Reactant 1

HCID 20467555HCID 20467555, compound

Product 1

HCID 54459Idazoxan

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 1118Sulfuric AcidSolvent

Procedure

2-(1,4-benzodioxan-2-yl)imidazoline acetate (1.0 g) is dissolved in a solution of 1 ml 50% aqueous sulfuric acid in 10 ml ethanol, and the solution evaporated to dryness. The product is suspended in ethanol and filtered, air dried and recrystallized from methanol/acetone to yield 2-(1,4-benzodioxan-2-yl)imidazoline: HSO4.

Workup

  1. customthe solution evaporated to dryness
  2. filtrationfiltered
  3. customair dried
  4. customrecrystallized from methanol/acetone

Sources & evidence

ORD record
ord-6448b057c989457a8e1aecdf8b4c6611
Source dataset
uspto-grants-1984_03
Patent number
US04436914

Reaction notes

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