Sodium Hydroxide → HCID 13036292, compound

HRID 1903698Notes

Reaction equation

HRID 1903698 reaction equation
O.Cl.[NH2:3][C@H:4]([C:7]([OH:9])=[O:8])[CH2:5][SH:6].[C:10]([OH:18])(=[O:17])[C@H:11]([CH2:13][C:14]([OH:16])=[O:15])[OH:12].[OH-].[Na+]>O>[C:10]([OH:18])(=[O:17])[C@H:11]([CH2:13][C:14]([OH:16])=[O:15])[OH:12].[NH2:3][C@H:4]([C:7]([OH:9])=[O:8])[CH2:5][SH:6].[NH2:3][C@H:4]([C:7]([OH:9])=[O:8])[CH2:5][SH:6]

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 23462L-Cysteine hydrochloride monohydrateHCID 222656L-Malic Acid

Product 1

HCID 13036292HCID 13036292, compoundYield 67.2%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

L-Cysteine hydrochloride monohydrate (20 g), L-malic acid (7.63 g) and sodium hydroxide (4.55 g) are dissolved in water (100 ml), and the mixture is reacted. The resulting aqueous solution is concentrated under reduced pressure until the total amount becomes 57 g, and the solution is allowed to stand at 10° C. overnight. The precipitated crystals are collected by filtration, washed with aqueous isopropyl alcohol and air-dried at 50° C. to give crystalline di-L-cysteine L-malate (14.4 g, yield: 67.2%).

Workup

  1. customthe mixture is reacted
  2. concentrationThe resulting aqueous solution is concentrated under reduced pressure until the total amount
  3. filtrationThe precipitated crystals are collected by filtration
  4. washwashed with aqueous isopropyl alcohol
  5. customair-dried at 50° C.

Sources & evidence

ORD record
ord-5441d44fd5394dc5ae372633497acd67
Source dataset
uspto-grants-1984_03
Patent number
US04438044

Reaction notes

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