反应详情

温度

50 °C

To a solution of ammonium thiocyanate (30.2 g) in anhydrous acetone (660 ml) was added dropwise benzoyl chloride (47.6 g) with stirring at 50° C. After refluxing for 1.5 hours, the mixture was cooled to ambient temperature. To the mixture containing benzoyl isothiocyanate was added dropwise a solution of 2-phenoxyaniline (47.6 g) in anhydrous acetone (300 ml). The reaction mixture was refluxed with stirring for 1.5 hours and then concentrated under reduced pressure to give crystals, which were washed twice with water and dried to give crystalline 1-(2-phenoxyphenyl)-3-benzoylthiourea.

1. temperatureAfter refluxing for 1.5 hours
2. temperaturethe mixture was cooled to ambient temperature
3. temperatureThe reaction mixture was refluxed
4. stirringwith stirring for 1.5 hours
5. concentrationconcentrated under reduced pressure
6. customto give crystals, which
7. washwere washed twice with water
8. customdried