Isopropylamine → 1-(2-Cyano-4-n-hexanoylamino-phenoxy)-3-isopropylamino-2-propanol

HRID 1903748Notes

Reaction equation

HRID 1903748 reaction equation
[C:1]([C:3]1[CH:13]=[C:12]([NH:14][C:15](=[O:21])[CH2:16][CH2:17][CH2:18][CH2:19][CH3:20])[CH:11]=[CH:10][C:4]=1[O:5][CH2:6][CH:7]1[O:9][CH2:8]1)#[N:2].[CH:22]([NH2:25])([CH3:24])[CH3:23]>C(O)C>[C:1]([C:3]1[CH:13]=[C:12]([NH:14][C:15](=[O:21])[CH2:16][CH2:17][CH2:18][CH2:19][CH3:20])[CH:11]=[CH:10][C:4]=1[O:5][CH2:6][CH:7]([OH:9])[CH2:8][NH:25][CH:22]([CH3:24])[CH3:23])#[N:2]

Participants

4

Reactant 2

HCID 6363IsopropylamineHCID 12939818HCID 12939818, compound

Product 1

HCID 127640311-(2-Cyano-4-n-hexanoylamino-phenoxy)-3-isopropylamino-2-propanol

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Ten grams (0.035 mol) of 1-(2-cyano-4-hexanoylamino-phenoxy)-2,3-epoxypropane were dissolved in 100 ml of ethanol and, after the addition of 8.3 gm (0.14 mol) of isopropylamine, the mixture was refluxed for one hour. The solvent was evaporated in vacuo, and the remaining residue solidified. It was recrystallized twice from acetonitrile. The white crystalline base was recovered by suction filtration and dried.

Workup

  1. temperaturethe mixture was refluxed for one hour
  2. customThe solvent was evaporated in vacuo
  3. customIt was recrystallized twice from acetonitrile
  4. filtrationThe white crystalline base was recovered by suction filtration
  5. customdried

Sources & evidence

ORD record
ord-07f3f5c02e1d4158a7a42e09fbd3d9e5
Source dataset
uspto-grants-1984_03
Patent number
US04438143

Reaction notes

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