Isopropylamine → 1-(2-Cyano-4-n-hexanoylamino-phenoxy)-3-isopropylamino-2-propanol

Participants

Reaction Steps

Ten grams (0.035 mol) of 1-(2-cyano-4-hexanoylamino-phenoxy)-2,3-epoxypropane were dissolved in 100 ml of ethanol and, after the addition of 8.3 gm (0.14 mol) of isopropylamine, the mixture was refluxed for one hour. The solvent was evaporated in vacuo, and the remaining residue solidified. It was recrystallized twice from acetonitrile. The white crystalline base was recovered by suction filtration and dried.

Provenance & Evidence