HCID 131713433, compound → HCID 131713432, compound

HRID 1903771Notes

Reaction equation

HRID 1903771 reaction equation
[Cl:1][C:2]1[S:6][C:5]([NH:7][CH:8]=[O:9])=[N:4][C:3]=1[C:10](=[N:37][O:38][CH2:39][C:40]([O:42][C:43]([CH3:46])([CH3:45])[CH3:44])=[O:41])[C:11]([NH:13][CH:14]1[C:35](=[O:36])[N:16]2[C:17]([C:22]([O:24]CC3C=CC([N+]([O-])=O)=CC=3)=[O:23])=[C:18]([Cl:21])[CH2:19][S:20][C@H:15]12)=[O:12]>CO.O1CCCC1.C(O)(=O)C.[C].[Pd]>[Cl:1][C:2]1[S:6][C:5]([NH:7][CH:8]=[O:9])=[N:4][C:3]=1[C:10](=[N:37][O:38][CH2:39][C:40]([O:42][C:43]([CH3:46])([CH3:45])[CH3:44])=[O:41])[C:11]([NH:13][CH:14]1[C:35](=[O:36])[N:16]2[C:17]([C:22]([OH:24])=[O:23])=[C:18]([Cl:21])[CH2:19][S:20][C@H:15]12)=[O:12]

Participants

6

Reactant 1

HCID 131713433HCID 131713433, compound

Product 1

HCID 131713432HCID 131713432, compoundYield 80.1%

Reagents, catalysts & solvents 4

HCID 178418390HCID 178418390, compoundCatalystHCID 176Acetic AcidSolventHCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

p-Nitrobenzyl 7-[2-(5-chloro-2-formamidothiazol-4-yl)-2-t-butoxycarbonylmethoxyiminoacetamido]-3-chloro-3-cephem-4-carboxylate (syn isomer) (6.2 g) was dissolved in a mixed solution of methanol (60 ml), tetrahydrofuran (40 ml) and glacial acetic acid (0.5 ml). After adding 10% palladium carbon (3.1 g) to the solution, the mixture was subjected to catalytic reduction at room temperature under atmospheric pressure. The catalyst was filtered off, and the filtrate was concentrated under reduced pressure. Water and ethyl acetate were added to the residue and the mixture was adjusted to pH 7.5 with saturated aqueous sodium bicarbonate. The separated aqueous layer was adjusted to pH 2.0 with 10% hydrochloric acid and extracted with ethyl acetate. The extract layer was washed with saturated aqueous sodium chloride and dried over magnesium sulfate. The solvent was evaporated to give 7-[2-(5-chloro-2-formamidothiazol-4-yl)-2-t-butoxycarbonylmethoxyiminoacetamido]-3-chloro-3-cephem-4-carboxylic acid (syn isomer) (4.03 g).

Workup

  1. customwas subjected to catalytic reduction at room temperature under atmospheric pressure
  2. filtrationThe catalyst was filtered off
  3. concentrationthe filtrate was concentrated under reduced pressure
  4. additionWater and ethyl acetate were added to the residue
  5. extractionextracted with ethyl acetate
  6. washThe extract layer was washed with saturated aqueous sodium chloride
  7. dry with materialdried over magnesium sulfate
  8. customThe solvent was evaporated

Sources & evidence

ORD record
ord-e322c2bfbd3546eba59a557f323c8f69
Source dataset
uspto-grants-1984_03
Patent number
US04438113

Reaction notes

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