((p-(Benzyloxy)phenoxy)methyl)oxirane → HCID 20237810, compound

HRID 1903806Notes

Reaction equation

HRID 1903806 reaction equation
C([O:8][C:9]1[CH:32]=[CH:31][C:12]([O:13][CH2:14][CH:15]([OH:30])[CH2:16][NH:17][CH2:18][CH2:19][NH:20][C:21]2[CH:29]=[CH:28][CH:27]=[C:26]3[C:22]=2[CH:23]=[N:24][NH:25]3)=[CH:11][CH:10]=1)C1C=CC=CC=1.C(OC1C=CC(OCC2C=CC=CC=2)=CC=1)C1OC1.NCCNC1C=CC=C2C=1C=NN2>CN(C)C=O>[OH:8][C:9]1[CH:10]=[CH:11][C:12]([O:13][CH2:14][CH:15]([OH:30])[CH2:16][NH:17][CH2:18][CH2:19][NH:20][C:21]2[CH:29]=[CH:28][CH:27]=[C:26]3[C:22]=2[CH:23]=[N:24][NH:25]3)=[CH:31][CH:32]=1

Participants

5

Reactant 3

HCID 119882((p-(Benzyloxy)phenoxy)methyl)oxiraneHCID 12818868HCID 12818868, compoundHCID 20237871HCID 20237871, compound

Product 1

HCID 20237810HCID 20237810, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The 1-(4-benzyloxyphenoxy)-3-[2-(indazol-4-ylamino)-ethylamino]-propan-2-ol used as starting material can be obtained in the following manner: 5.1 g. 4-benzyloxyphenyl glycidyl ether and 7.0 g. 4-(2-aminoethylamino)-indazole are dissolved in 10 ml. dimethylformamide and left to stand for 2 days at ambient temperature. The reaction mixture is then digested by the addition of 20 ml. methanol, filtered off with suction and then washed with methanol. There are obtained 5.0 g. (58% of theory) of the desired product in the form of colorless crystals; m.p. 151°-153° C.

Workup

  1. customcan be obtained in the following manner
  2. additionThe reaction mixture is then digested by the addition of 20 ml
  3. filtrationmethanol, filtered off with suction
  4. washwashed with methanol
  5. customThere are obtained 5.0 g

Sources & evidence

ORD record
ord-8317245eb3354932bd33c510f6d00035
Source dataset
uspto-grants-1984_03
Patent number
US04438128

Reaction notes

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