Phenyl glycidyl ether → HCID 20237859, compound

Participants

Reaction Steps

3.0 g. Phenyl glycidyl ether and 7.0 g. 7-(2-aminoethylamino)-indazole are stirred for 10 hours at 70° C. in 20 ml. isopropyl alcohol. The reaction mixture is then evaporated and purified chromatographically on a silica gel column in the manner described in Example 24. The residue of the pure fractions is digested with ethyl acetate and then recrystallized from ethyl acetate, with the use of active charcoal and fullers' earth. There are obtained 2.3 g. (35% of theory) of the desired product in the form of colorless crystals; m.p. 117°-119° C.

Provenance & Evidence