Phenyl glycidyl ether → HCID 20237859, compound

HRID 1903809Notes

Reaction equation

HRID 1903809 reaction equation
[CH2:1]([O:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[CH:2]1[O:4][CH2:3]1.[NH2:12][CH2:13][CH2:14][NH:15][C:16]1[CH:17]=[CH:18][CH:19]=[C:20]2[C:24]=1[NH:23][N:22]=[CH:21]2>C(O)(C)C>[O:5]([CH2:1][CH:2]([OH:4])[CH2:3][NH:12][CH2:13][CH2:14][NH:15][C:16]1[CH:17]=[CH:18][CH:19]=[C:20]2[C:24]=1[NH:23][N:22]=[CH:21]2)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

Participants

4

Reactant 2

HCID 31217Phenyl glycidyl etherHCID 19354417HCID 19354417, compound

Product 1

HCID 20237859HCID 20237859, compoundYield 67%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

3.0 g. Phenyl glycidyl ether and 7.0 g. 7-(2-aminoethylamino)-indazole are stirred for 10 hours at 70° C. in 20 ml. isopropyl alcohol. The reaction mixture is then evaporated and purified chromatographically on a silica gel column in the manner described in Example 24. The residue of the pure fractions is digested with ethyl acetate and then recrystallized from ethyl acetate, with the use of active charcoal and fullers' earth. There are obtained 2.3 g. (35% of theory) of the desired product in the form of colorless crystals; m.p. 117°-119° C.

Workup

  1. customThe reaction mixture is then evaporated
  2. custompurified chromatographically on a silica gel column in the manner
  3. customrecrystallized from ethyl acetate, with the use of active charcoal and fullers' earth
  4. customThere are obtained 2.3 g

Sources & evidence

ORD record
ord-bfc5ae7ade644079a86be0e38c546c66
Source dataset
uspto-grants-1984_03
Patent number
US04438128

Reaction notes

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