HCID 4350219, compound → HCID 13290537, compound

HRID 1903874Notes

Reaction equation

HRID 1903874 reaction equation
[N+:1]([C:4]1[CH:9]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:7]=[CH:6][C:5]=1[NH:14][C:15]1[CH:28]=[CH:27][C:18]([O:19][CH:20]([CH3:26])[C:21]([O:23][CH2:24][CH3:25])=[O:22])=[CH:17][CH:16]=1)([O-])=O.[H][H]>O1CCCC1.[Pd]>[NH2:1][C:4]1[CH:9]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:7]=[CH:6][C:5]=1[NH:14][C:15]1[CH:16]=[CH:17][C:18]([O:19][CH:20]([CH3:26])[C:21]([O:23][CH2:24][CH3:25])=[O:22])=[CH:27][CH:28]=1

Participants

5

Reactant 2

HCID 4350219HCID 4350219, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 13290537HCID 13290537, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

1B, in tetrahydrofuran, was treated with hydrogen (40 psi pressure in a Parr-shaker, 10% palladium-on-carbon catalyst), to give ethyl 2-(4-(2-amino-4-(trifluoromethyl)phenylamino)phenoxy)propionate (1C), as a solid, m.p.: 78° C.

Sources & evidence

ORD record
ord-e0d935cb7da64f84bf53e2e1d06aafa1
Source dataset
uspto-grants-1984_03
Patent number
US04439226

Reaction notes

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